Depressive illness in Parkinson’s disease – indication of a more advanced and widespread neurodegenerative process?
Identifieur interne : 000692 ( Main/Corpus ); précédent : 000691; suivant : 000693Depressive illness in Parkinson’s disease – indication of a more advanced and widespread neurodegenerative process?
Auteurs : S. E. P Lhagen ; M. Carlsson ; E. Curman ; J. W Linder ; A. GranérusSource :
- Acta Neurologica Scandinavica [ 0001-6314 ] ; 2008-05.
English descriptors
Abstract
Objective – The aims were to study if the type and complexity of Parkinsonian symptoms, as well as treatment, could be related to the occurrence and severity of later depressive symptoms. Furthermore, the aim was to study if there is a different depressive symptomatology in Parkinson’s disease (PD) patients compared with depressive illness in an age‐matched group of patients with major depression but without Parkinson’s disease. Methods – Eleven PD‐patients with major depression (MD) were compared to 14 PD‐patients without depression and to 12 MD patients without PD. Results – PD patients who later developed a depressive illness were younger at the debut of PD than patients without depression (P < 0.05). At inclusion the depressed PD patients were more disabled than PD patients without depression with higher level in the H&Y scale (P<0.05), and they had more involuntary movements according to Unified Parkinson’s Disease Rating Scale (UPDRS IV) (P < 0.01). A family history of depression was found in one third of the depressed non‐parkinsonian patients but in none of the PD groups. Sleep disturbances were significantly more common among depressed PD patients than in PD patients without depression but even more common in depressed patients without PD. Conclusions – Depressed PD patients had a longer duration of PD and more severe motor symptoms than PD patients without depression, although tremor as an initial symptom seemed to be more common in PD without a later depression. It cannot be excluded that depression in PD reflects a more advanced and widespread neurodegeneration, including serotonergic as well as dopaminergic neurons. Sleep disturbances is common and could be overlooked as an expression of depression.
Url:
DOI: 10.1111/j.1600-0404.2007.00986.x
Links to Exploration step
ISTEX:3A62903EDBC50E9B91B599B3097A7F36D3DBDA15Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Depressive illness in Parkinson’s disease – indication of a more advanced and widespread neurodegenerative process?</title><author><name sortKey="P Lhagen, S E" sort="P Lhagen, S E" uniqKey="P Lhagen S" first="S. E." last="P Lhagen">S. E. P Lhagen</name><affiliation><mods:affiliation>Department of Clinical neuroscience, Division of Neurology Huddinge, Karolinska Institute, Stockholm, Sweden</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Neurology, Clinic of Medicine, Ryhov Hospital, Jönköping, Sweden</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Neurology, Karolinska University Hospital Huddinge, Stockholm, Sweden;</mods:affiliation></affiliation></author><author><name sortKey="Carlsson, M" sort="Carlsson, M" uniqKey="Carlsson M" first="M." last="Carlsson">M. Carlsson</name><affiliation><mods:affiliation>Department of Neurology, Clinic of Medicine, Ryhov Hospital, Jönköping, Sweden</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Neuroscience and Locomotion, Division of Geriatrics, Faculty of Health Sciences, Linköping University, Linköping, Sweden</mods:affiliation></affiliation></author><author><name sortKey="Curman, E" sort="Curman, E" uniqKey="Curman E" first="E." last="Curman">E. Curman</name><affiliation><mods:affiliation>Primary Care Centre, Eholmen, Linköping, Sweden</mods:affiliation></affiliation></author><author><name sortKey="W Linder, J" sort="W Linder, J" uniqKey="W Linder J" first="J." last="W Linder">J. W Linder</name><affiliation><mods:affiliation>Department of Psychiatry, Sahlgrenska University Hospital, Mölndal, Sweden</mods:affiliation></affiliation></author><author><name sortKey="Granerus, A" sort="Granerus, A" uniqKey="Granerus A" first="A." last="Granérus">A. Granérus</name><affiliation><mods:affiliation>Department of Neuroscience and Locomotion, Division of Geriatrics, Faculty of Health Sciences, Linköping University, Linköping, Sweden</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:3A62903EDBC50E9B91B599B3097A7F36D3DBDA15</idno><date when="2008" year="2008">2008</date><idno type="doi">10.1111/j.1600-0404.2007.00986.x</idno><idno type="url">https://api.istex.fr/document/3A62903EDBC50E9B91B599B3097A7F36D3DBDA15/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">000692</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Depressive illness in Parkinson’s disease – indication of a more advanced and widespread neurodegenerative process?</title><author><name sortKey="P Lhagen, S E" sort="P Lhagen, S E" uniqKey="P Lhagen S" first="S. E." last="P Lhagen">S. E. P Lhagen</name><affiliation><mods:affiliation>Department of Clinical neuroscience, Division of Neurology Huddinge, Karolinska Institute, Stockholm, Sweden</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Neurology, Clinic of Medicine, Ryhov Hospital, Jönköping, Sweden</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Neurology, Karolinska University Hospital Huddinge, Stockholm, Sweden;</mods:affiliation></affiliation></author><author><name sortKey="Carlsson, M" sort="Carlsson, M" uniqKey="Carlsson M" first="M." last="Carlsson">M. Carlsson</name><affiliation><mods:affiliation>Department of Neurology, Clinic of Medicine, Ryhov Hospital, Jönköping, Sweden</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Neuroscience and Locomotion, Division of Geriatrics, Faculty of Health Sciences, Linköping University, Linköping, Sweden</mods:affiliation></affiliation></author><author><name sortKey="Curman, E" sort="Curman, E" uniqKey="Curman E" first="E." last="Curman">E. Curman</name><affiliation><mods:affiliation>Primary Care Centre, Eholmen, Linköping, Sweden</mods:affiliation></affiliation></author><author><name sortKey="W Linder, J" sort="W Linder, J" uniqKey="W Linder J" first="J." last="W Linder">J. W Linder</name><affiliation><mods:affiliation>Department of Psychiatry, Sahlgrenska University Hospital, Mölndal, Sweden</mods:affiliation></affiliation></author><author><name sortKey="Granerus, A" sort="Granerus, A" uniqKey="Granerus A" first="A." last="Granérus">A. Granérus</name><affiliation><mods:affiliation>Department of Neuroscience and Locomotion, Division of Geriatrics, Faculty of Health Sciences, Linköping University, Linköping, Sweden</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Acta Neurologica Scandinavica</title><idno type="ISSN">0001-6314</idno><idno type="eISSN">1600-0404</idno><imprint><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2008-05">2008-05</date><biblScope unit="volume">117</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="295">295</biblScope><biblScope unit="page" to="304">304</biblScope></imprint><idno type="ISSN">0001-6314</idno></series><idno type="istex">3A62903EDBC50E9B91B599B3097A7F36D3DBDA15</idno><idno type="DOI">10.1111/j.1600-0404.2007.00986.x</idno><idno type="ArticleID">ANE986</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0001-6314</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease</term><term>major depression</term><term>neurodegenerative disorders</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Objective – The aims were to study if the type and complexity of Parkinsonian symptoms, as well as treatment, could be related to the occurrence and severity of later depressive symptoms. Furthermore, the aim was to study if there is a different depressive symptomatology in Parkinson’s disease (PD) patients compared with depressive illness in an age‐matched group of patients with major depression but without Parkinson’s disease. Methods – Eleven PD‐patients with major depression (MD) were compared to 14 PD‐patients without depression and to 12 MD patients without PD. Results – PD patients who later developed a depressive illness were younger at the debut of PD than patients without depression (P < 0.05). At inclusion the depressed PD patients were more disabled than PD patients without depression with higher level in the H&Y scale (P<0.05), and they had more involuntary movements according to Unified Parkinson’s Disease Rating Scale (UPDRS IV) (P < 0.01). A family history of depression was found in one third of the depressed non‐parkinsonian patients but in none of the PD groups. Sleep disturbances were significantly more common among depressed PD patients than in PD patients without depression but even more common in depressed patients without PD. Conclusions – Depressed PD patients had a longer duration of PD and more severe motor symptoms than PD patients without depression, although tremor as an initial symptom seemed to be more common in PD without a later depression. It cannot be excluded that depression in PD reflects a more advanced and widespread neurodegeneration, including serotonergic as well as dopaminergic neurons. Sleep disturbances is common and could be overlooked as an expression of depression.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>S. E. Pålhagen</name><affiliations><json:string>Department of Clinical neuroscience, Division of Neurology Huddinge, Karolinska Institute, Stockholm, Sweden</json:string><json:string>Department of Neurology, Clinic of Medicine, Ryhov Hospital, Jönköping, Sweden</json:string><json:string>Department of Neurology, Karolinska University Hospital Huddinge, Stockholm, Sweden;</json:string></affiliations></json:item><json:item><name>M. Carlsson</name><affiliations><json:string>Department of Neurology, Clinic of Medicine, Ryhov Hospital, Jönköping, Sweden</json:string><json:string>Department of Neuroscience and Locomotion, Division of Geriatrics, Faculty of Health Sciences, Linköping University, Linköping, Sweden</json:string></affiliations></json:item><json:item><name>E. Curman</name><affiliations><json:string>Primary Care Centre, Eholmen, Linköping, Sweden</json:string></affiliations></json:item><json:item><name>J. Wålinder</name><affiliations><json:string>Department of Psychiatry, Sahlgrenska University Hospital, Mölndal, Sweden</json:string></affiliations></json:item><json:item><name>A.‐K. Granérus</name><affiliations><json:string>Department of Neuroscience and Locomotion, Division of Geriatrics, Faculty of Health Sciences, Linköping University, Linköping, Sweden</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>major depression</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>neurodegenerative disorders</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Parkinson's disease</value></json:item></subject><articleId><json:string>ANE986</json:string></articleId><language><json:string>eng</json:string></language><abstract>Objective – The aims were to study if the type and complexity of Parkinsonian symptoms, as well as treatment, could be related to the occurrence and severity of later depressive symptoms. Furthermore, the aim was to study if there is a different depressive symptomatology in Parkinson’s disease (PD) patients compared with depressive illness in an age‐matched group of patients with major depression but without Parkinson’s disease. Methods – Eleven PD‐patients with major depression (MD) were compared to 14 PD‐patients without depression and to 12 MD patients without PD. Results – PD patients who later developed a depressive illness were younger at the debut of PD than patients without depression (P > 0.05). At inclusion the depressed PD patients were more disabled than PD patients without depression with higher level in the H&Y scale (P>0.05), and they had more involuntary movements according to Unified Parkinson’s Disease Rating Scale (UPDRS IV) (P > 0.01). A family history of depression was found in one third of the depressed non‐parkinsonian patients but in none of the PD groups. Sleep disturbances were significantly more common among depressed PD patients than in PD patients without depression but even more common in depressed patients without PD. Conclusions – Depressed PD patients had a longer duration of PD and more severe motor symptoms than PD patients without depression, although tremor as an initial symptom seemed to be more common in PD without a later depression. It cannot be excluded that depression in PD reflects a more advanced and widespread neurodegeneration, including serotonergic as well as dopaminergic neurons. Sleep disturbances is common and could be overlooked as an expression of depression.</abstract><qualityIndicators><score>8</score><pdfVersion>1.3</pdfVersion><pdfPageSize>595.276 x 782.362 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>3</keywordCount><abstractCharCount>1745</abstractCharCount><pdfWordCount>5246</pdfWordCount><pdfCharCount>35197</pdfCharCount><pdfPageCount>10</pdfPageCount><abstractWordCount>268</abstractWordCount></qualityIndicators><title>Depressive illness in Parkinson’s disease – indication of a more advanced and widespread neurodegenerative process?</title><genre><json:string>article</json:string></genre><host><volume>117</volume><publisherId><json:string>ANE</json:string></publisherId><pages><total>10</total><last>304</last><first>295</first></pages><issn><json:string>0001-6314</json:string></issn><issue>5</issue><genre><json:string>Journal</json:string></genre><language><json:string>unknown</json:string></language><eissn><json:string>1600-0404</json:string></eissn><title>Acta Neurologica Scandinavica</title><doi><json:string>10.1111/(ISSN)1600-0404</json:string></doi></host><publicationDate>2008</publicationDate><copyrightDate>2008</copyrightDate><doi><json:string>10.1111/j.1600-0404.2007.00986.x</json:string></doi><id>3A62903EDBC50E9B91B599B3097A7F36D3DBDA15</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/3A62903EDBC50E9B91B599B3097A7F36D3DBDA15/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/3A62903EDBC50E9B91B599B3097A7F36D3DBDA15/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/3A62903EDBC50E9B91B599B3097A7F36D3DBDA15/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Depressive illness in Parkinson’s disease – indication of a more advanced and widespread neurodegenerative process?</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><availability><p>WILEY</p></availability><date>2008</date></publicationStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Depressive illness in Parkinson’s disease – indication of a more advanced and widespread neurodegenerative process?</title><author><persName><forename type="first">S. E.</forename><surname>Pålhagen</surname></persName><affiliation>Department of Clinical neuroscience, Division of Neurology Huddinge, Karolinska Institute, Stockholm, Sweden</affiliation><affiliation>Department of Neurology, Clinic of Medicine, Ryhov Hospital, Jönköping, Sweden</affiliation><affiliation>Department of Neurology, Karolinska University Hospital Huddinge, Stockholm, Sweden;</affiliation></author><author><persName><forename type="first">M.</forename><surname>Carlsson</surname></persName><affiliation>Department of Neurology, Clinic of Medicine, Ryhov Hospital, Jönköping, Sweden</affiliation><affiliation>Department of Neuroscience and Locomotion, Division of Geriatrics, Faculty of Health Sciences, Linköping University, Linköping, Sweden</affiliation></author><author><persName><forename type="first">E.</forename><surname>Curman</surname></persName><affiliation>Primary Care Centre, Eholmen, Linköping, Sweden</affiliation></author><author><persName><forename type="first">J.</forename><surname>Wålinder</surname></persName><affiliation>Department of Psychiatry, Sahlgrenska University Hospital, Mölndal, Sweden</affiliation></author><author><persName><forename type="first">A.‐K.</forename><surname>Granérus</surname></persName><affiliation>Department of Neuroscience and Locomotion, Division of Geriatrics, Faculty of Health Sciences, Linköping University, Linköping, Sweden</affiliation></author></analytic><monogr><title level="j">Acta Neurologica Scandinavica</title><idno type="pISSN">0001-6314</idno><idno type="eISSN">1600-0404</idno><idno type="DOI">10.1111/(ISSN)1600-0404</idno><imprint><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2008-05"></date><biblScope unit="volume">117</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="295">295</biblScope><biblScope unit="page" to="304">304</biblScope></imprint></monogr><idno type="istex">3A62903EDBC50E9B91B599B3097A7F36D3DBDA15</idno><idno type="DOI">10.1111/j.1600-0404.2007.00986.x</idno><idno type="ArticleID">ANE986</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2008</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Objective – The aims were to study if the type and complexity of Parkinsonian symptoms, as well as treatment, could be related to the occurrence and severity of later depressive symptoms. Furthermore, the aim was to study if there is a different depressive symptomatology in Parkinson’s disease (PD) patients compared with depressive illness in an age‐matched group of patients with major depression but without Parkinson’s disease. Methods – Eleven PD‐patients with major depression (MD) were compared to 14 PD‐patients without depression and to 12 MD patients without PD. Results – PD patients who later developed a depressive illness were younger at the debut of PD than patients without depression (P < 0.05). At inclusion the depressed PD patients were more disabled than PD patients without depression with higher level in the H&Y scale (P<0.05), and they had more involuntary movements according to Unified Parkinson’s Disease Rating Scale (UPDRS IV) (P < 0.01). A family history of depression was found in one third of the depressed non‐parkinsonian patients but in none of the PD groups. Sleep disturbances were significantly more common among depressed PD patients than in PD patients without depression but even more common in depressed patients without PD. Conclusions – Depressed PD patients had a longer duration of PD and more severe motor symptoms than PD patients without depression, although tremor as an initial symptom seemed to be more common in PD without a later depression. It cannot be excluded that depression in PD reflects a more advanced and widespread neurodegeneration, including serotonergic as well as dopaminergic neurons. Sleep disturbances is common and could be overlooked as an expression of depression.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>major depression</term></item><item><term>neurodegenerative disorders</term></item><item><term>Parkinson's disease</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2008-05">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/3A62903EDBC50E9B91B599B3097A7F36D3DBDA15/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Blackwell Publishing Ltd</publisherName><publisherLoc>Oxford, UK</publisherLoc></publisherInfo><doi origin="wiley" registered="yes">10.1111/(ISSN)1600-0404</doi><issn type="print">0001-6314</issn><issn type="electronic">1600-0404</issn><idGroup><id type="product" value="ANE"></id><id type="publisherDivision" value="ST"></id></idGroup><titleGroup><title type="main" sort="ACTA NEUROLOGICA SCANDINAVICA">Acta Neurologica Scandinavica</title></titleGroup></publicationMeta><publicationMeta level="part" position="05005"><doi origin="wiley">10.1111/ane.2008.117.issue-5</doi><numberingGroup><numbering type="journalVolume" number="117">117</numbering><numbering type="journalIssue" number="5">5</numbering></numberingGroup><coverDate startDate="2008-05">May 2008</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="1" status="forIssue"><doi origin="wiley">10.1111/j.1600-0404.2007.00986.x</doi><idGroup><id type="unit" value="ANE986"></id></idGroup><countGroup><count type="pageTotal" number="10"></count></countGroup><titleGroup><title type="tocHeading1"><i>Original articles</i></title></titleGroup><copyright>© 2008 The Authors</copyright><eventGroup><event type="firstOnline" date="2008-02-13"></event><event type="publishedOnlineFinalForm" date="2008-02-13"></event><event type="xmlConverted" agent="Converter:BPG_TO_WML3G version:2.3.5 mode:FullText source:FullText result:FullText" date="2010-04-06"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:4.0.1" date="2014-03-15"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-14"></event></eventGroup><numberingGroup><numbering type="pageFirst" number="295">295</numbering><numbering type="pageLast" number="304">304</numbering></numberingGroup><correspondenceTo>Dr Sven E. Pålhagen, Department of Neurology, Karolinska University Hospital Huddinge, 141 86 Stockholm, Sweden
Tel.: +46 8 585 80 00
Fax: +46 8 585 820 59
e‐mail: <email>sven.palhagen@karolinska.se</email></correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:ANE.ANE986.pdf"></link></linkGroup></publicationMeta><contentMeta><unparsedEditorialHistory>Accepted for publication December 11, 2007</unparsedEditorialHistory><countGroup><count type="figureTotal" number="0"></count><count type="tableTotal" number="4"></count></countGroup><titleGroup><title type="main">Depressive illness in Parkinson’s disease – indication of a more advanced and widespread neurodegenerative process?</title><title type="shortAuthors"><b>Pålhagen et al.</b></title><title type="short"><b>Depressive illness in Parkinson’s disease</b></title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#a1 #a2 #a3"><personName><givenNames>S. E.</givenNames><familyName>Pålhagen</familyName></personName></creator><creator creatorRole="author" xml:id="cr2" affiliationRef="#a2 #a4"><personName><givenNames>M.</givenNames><familyName>Carlsson</familyName></personName></creator><creator creatorRole="author" xml:id="cr3" affiliationRef="#a5"><personName><givenNames>E.</givenNames><familyName>Curman</familyName></personName></creator><creator creatorRole="author" xml:id="cr4" affiliationRef="#a6"><personName><givenNames>J.</givenNames><familyName>Wålinder</familyName></personName></creator><creator creatorRole="author" xml:id="cr5" affiliationRef="#a4"><personName><givenNames> A.‐K.</givenNames><familyName>Granérus</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="a1" countryCode="SE"><unparsedAffiliation>Department of Clinical neuroscience, Division of Neurology Huddinge, Karolinska Institute, Stockholm, Sweden</unparsedAffiliation></affiliation><affiliation xml:id="a2" countryCode="SE"><unparsedAffiliation>Department of Neurology, Clinic of Medicine, Ryhov Hospital, Jönköping, Sweden</unparsedAffiliation></affiliation><affiliation xml:id="a3" countryCode="SE"><unparsedAffiliation>Department of Neurology, Karolinska University Hospital Huddinge, Stockholm, Sweden;</unparsedAffiliation></affiliation><affiliation xml:id="a4" countryCode="SE"><unparsedAffiliation>Department of Neuroscience and Locomotion, Division of Geriatrics, Faculty of Health Sciences, Linköping University, Linköping, Sweden</unparsedAffiliation></affiliation><affiliation xml:id="a5" countryCode="SE"><unparsedAffiliation>Primary Care Centre, Eholmen, Linköping, Sweden</unparsedAffiliation></affiliation><affiliation xml:id="a6" countryCode="SE"><unparsedAffiliation>Department of Psychiatry, Sahlgrenska University Hospital, Mölndal, Sweden</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en"><keyword xml:id="k1">major depression</keyword><keyword xml:id="k2">neurodegenerative disorders</keyword><keyword xml:id="k3">Parkinson's disease</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><!-- Pålhagen SE, Carlsson M, Curman E, Wålinder J, Granérus A-K. Depressive illness in Parkinson’s disease – indication of a more advanced and widespread neurodegenerative process?
Acta Neurol Scand 2008: 117: 295–304.
© 2008 The Authors Journal compilation © 2008 Blackwell Munksgaard. --><p><b>Objective – </b> The aims were to study if the type and complexity of Parkinsonian symptoms, as well as treatment, could be related to the occurrence and severity of later depressive symptoms. Furthermore, the aim was to study if there is a different depressive symptomatology in Parkinson’s disease (PD) patients compared with depressive illness in an age‐matched group of patients with major depression but without Parkinson’s disease.</p><p><b>Methods – </b> Eleven PD‐patients with major depression (MD) were compared to 14 PD‐patients without depression and to 12 MD patients without PD.</p><p><b>Results – </b> PD patients who later developed a depressive illness were younger at the debut of PD than patients without depression (<i>P</i> < 0.05). At inclusion the depressed PD patients were more disabled than PD patients without depression with higher level in the H&Y scale (<i>P</i><0.05), and they had more involuntary movements according to Unified Parkinson’s Disease Rating Scale (UPDRS IV) (<i>P</i> < 0.01). A family history of depression was found in one third of the depressed non‐parkinsonian patients but in none of the PD groups. Sleep disturbances were significantly more common among depressed PD patients than in PD patients without depression but even more common in depressed patients without PD.</p><p><b>Conclusions – </b> Depressed PD patients had a longer duration of PD and more severe motor symptoms than PD patients without depression, although tremor as an initial symptom seemed to be more common in PD without a later depression. It cannot be excluded that depression in PD reflects a more advanced and widespread neurodegeneration, including serotonergic as well as dopaminergic neurons. Sleep disturbances is common and could be overlooked as an expression of depression.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Depressive illness in Parkinson’s disease – indication of a more advanced and widespread neurodegenerative process?</title></titleInfo><titleInfo type="abbreviated"><title>Depressive illness in Parkinson’s disease</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Depressive illness in Parkinson’s disease – indication of a more advanced and widespread neurodegenerative process?</title></titleInfo><name type="personal"><namePart type="given">S. E.</namePart><namePart type="family">Pålhagen</namePart><affiliation>Department of Clinical neuroscience, Division of Neurology Huddinge, Karolinska Institute, Stockholm, Sweden</affiliation><affiliation>Department of Neurology, Clinic of Medicine, Ryhov Hospital, Jönköping, Sweden</affiliation><affiliation>Department of Neurology, Karolinska University Hospital Huddinge, Stockholm, Sweden;</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Carlsson</namePart><affiliation>Department of Neurology, Clinic of Medicine, Ryhov Hospital, Jönköping, Sweden</affiliation><affiliation>Department of Neuroscience and Locomotion, Division of Geriatrics, Faculty of Health Sciences, Linköping University, Linköping, Sweden</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E.</namePart><namePart type="family">Curman</namePart><affiliation>Primary Care Centre, Eholmen, Linköping, Sweden</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Wålinder</namePart><affiliation>Department of Psychiatry, Sahlgrenska University Hospital, Mölndal, Sweden</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.‐K.</namePart><namePart type="family">Granérus</namePart><affiliation>Department of Neuroscience and Locomotion, Division of Geriatrics, Faculty of Health Sciences, Linköping University, Linköping, Sweden</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><place><placeTerm type="text">Oxford, UK</placeTerm></place><dateIssued encoding="w3cdtf">2008-05</dateIssued><edition>Accepted for publication December 11, 2007</edition><copyrightDate encoding="w3cdtf">2008</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="tables">4</extent></physicalDescription><abstract lang="en">Objective – The aims were to study if the type and complexity of Parkinsonian symptoms, as well as treatment, could be related to the occurrence and severity of later depressive symptoms. Furthermore, the aim was to study if there is a different depressive symptomatology in Parkinson’s disease (PD) patients compared with depressive illness in an age‐matched group of patients with major depression but without Parkinson’s disease. Methods – Eleven PD‐patients with major depression (MD) were compared to 14 PD‐patients without depression and to 12 MD patients without PD. Results – PD patients who later developed a depressive illness were younger at the debut of PD than patients without depression (P < 0.05). At inclusion the depressed PD patients were more disabled than PD patients without depression with higher level in the H&Y scale (P<0.05), and they had more involuntary movements according to Unified Parkinson’s Disease Rating Scale (UPDRS IV) (P < 0.01). A family history of depression was found in one third of the depressed non‐parkinsonian patients but in none of the PD groups. Sleep disturbances were significantly more common among depressed PD patients than in PD patients without depression but even more common in depressed patients without PD. Conclusions – Depressed PD patients had a longer duration of PD and more severe motor symptoms than PD patients without depression, although tremor as an initial symptom seemed to be more common in PD without a later depression. It cannot be excluded that depression in PD reflects a more advanced and widespread neurodegeneration, including serotonergic as well as dopaminergic neurons. Sleep disturbances is common and could be overlooked as an expression of depression.</abstract><subject lang="en"><genre>Keywords</genre><topic>major depression</topic><topic>neurodegenerative disorders</topic><topic>Parkinson's disease</topic></subject><relatedItem type="host"><titleInfo><title>Acta Neurologica Scandinavica</title></titleInfo><genre type="Journal">journal</genre><identifier type="ISSN">0001-6314</identifier><identifier type="eISSN">1600-0404</identifier><identifier type="DOI">10.1111/(ISSN)1600-0404</identifier><identifier type="PublisherID">ANE</identifier><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>117</number></detail><detail type="issue"><caption>no.</caption><number>5</number></detail><extent unit="pages"><start>295</start><end>304</end><total>10</total></extent></part></relatedItem><identifier type="istex">3A62903EDBC50E9B91B599B3097A7F36D3DBDA15</identifier><identifier type="DOI">10.1111/j.1600-0404.2007.00986.x</identifier><identifier type="ArticleID">ANE986</identifier><accessCondition type="use and reproduction" contentType="copyright">© 2008 The Authors</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Blackwell Publishing Ltd</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/Main/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000692 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Corpus/biblio.hfd -nk 000692 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonV1
|flux= Main
|étape= Corpus
|type= RBID
|clé= ISTEX:3A62903EDBC50E9B91B599B3097A7F36D3DBDA15
|texte= Depressive illness in Parkinson’s disease – indication of a more advanced and widespread neurodegenerative process?
}}
| This area was generated with Dilib version V0.6.23. |  |